All About Orilissa
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What are some continuously requested questions on Orilissa?
What are some continuously requested questions on Orilissa?
Find solutions to some generally requested questions on Orilissa.
Does stopping Orilissa trigger withdrawal signs?
No, stopping Orilissa isn’t identified to trigger withdrawal signs. (Withdrawal signs can happen while you cease taking a drug your physique depends upon to operate like regular.) Some individuals’s endometriosis signs worsen after stopping Orilissa therapy, although.
If you will have questions on stopping Orilissa, discuss together with your physician. Do not cease taking the drug except they inform you to take action.
How does Orilissa work?
Orilissa’s mechanism of motion (the way it works) for treating endometriosis ache is to dam the discharge of sure hormones made by your physique. These hormones embody follicle-stimulating hormone and luteinizing hormone.
Blocking these hormones decreases the degrees of estrogen and progesterone in your physique. This decreases tissue buildup exterior your uterus.
For extra details about how estrogen, progesterone, and endometriosis are associated, see “What is Orilissa used for?” beneath.
If you will have extra questions on how Orilissa works, discuss together with your pharmacist or physician.
What ought to I find out about Orilissa vs. Lupron?
What ought to I find out about Orilissa vs. Lupron?
Orilissa and Lupron are each prescription medicines used to deal with ache brought on by endometriosis. They belong to totally different teams of medicine. But they each work to lower ranges of sure hormones in your physique, corresponding to estrogen and progesterone.
Orilissa and Lupron have some variations. The solely type of Lupron obtainable is Lupron Depot. It’s given as an injection right into a muscle by a healthcare skilled each 3 months. Orilissa, however, is a pill that you just swallow a couple of times every day.
To study extra about Lupron and Lupron Depot, discuss together with your physician. You may try this side-by-side comparability of Orilissa and Lupron.
What is Orilissa used for?
What is Orilissa used for?
Orilissa is utilized in grownup females* to deal with average or extreme ache brought on by endometriosis.
Endometriosis is a situation that causes tissue normally discovered lining the uterus to develop exterior the uterus. The tissue could develop on surrounding organs, corresponding to your ovaries, fallopian tubes, and the liner of your pelvis. The commonest signs of endometriosis are pelvic ache and infertility.
It’s not totally understood why endometriosis develops. But it’s identified that the hormones estrogen and progesterone are concerned. These are intercourse hormones that your physique makes naturally. They play a significant function in your menstrual cycle, together with sending indicators that make the liner of your uterus develop. Orilissa works by blocking these indicators from being despatched. This helps cease the expansion of each the liner of your uterus and endometriosis tissue.
Your physician could suggest taking Orilissa by itself, or with different medicine. For instance, your physician could suggest taking a nonsteroidal anti-inflammatory drug (NSAID), corresponding to ibuprofen (Advil, Motrin), as wanted.
* In this text, we use the time period “ female” to confer with somebody’s intercourse assigned at start. For details about the distinction between intercourse and gender, see this text.
Limit of use
You shouldn’t take Orilissa for greater than 24 months, as a result of danger of bone loss. If you’re taking Orilissa twice every day or have liver issues, you shouldn’t take the drug for greater than 6 months.
It isn’t identified whether or not bone loss brought on by Orilissa is totally reversible, even if you happen to cease taking the drug. And it isn’t identified if this bone loss will increase the danger of damaged bones as you age.
Taking a better dosage of Orilissa will increase your danger of bone loss. And the longer you’re taking Orilissa, the extra this danger will increase. Your physician could suggest that you just take a vitamin D and calcium complement when you’re taking Orilissa. They can also recommend different methods to help your bone well being.
Before you start taking Orilissa, inform your physician if you happen to’ve ever damaged a bone. You also needs to inform them about all of the medicines you’re taking, to allow them to see if any trigger bone loss. Your physician could order an X-ray to test your bone well being.
Drug group or drug titleDrug examples
sure contraception capsules that include estrogen• ethinyl estradiol/drospirenone (Gianvi, Loryna, Nikki, Yasmin, Yaz)
• ethinyl estradiol/norethindrone (Leena, Nortrel, Ortho-Novum, Ovcon)
• ethinyl estradiol/levonorgestrel (Altavera, Amethia, Daysee, Lessina, Seasonique)
contraception capsules that include progestin• norethindrone (Nor-QD, Jolivette)
• ethinyl estradiol/drospirenone (Gianvi, Loryna, Nikki, Yasmin, Yaz)
the contraception vaginal ring, ethinyl estradiol/etonogestrel (NuvaRing)—
clarithromycin—
sure antifungals• itraconazole (Sporanox)
• ketoconazole
cyclosporine(Gengraf, Neoral, Sandimmune)—
gemfibrozil (Lopid)—
carbamazepine (Tegretol)—
sure coronary heart medicines• digoxin (Lanoxin)
• rivaroxaban
amlodipine (Norvasc)—
rosuvastatin (Crestor)—
zolpidem (Ambien)—
What must be thought-about earlier than taking Orilissa?
Below is necessary info it is best to contemplate earlier than taking Orilissa.
Interactions
Taking a drugs with sure vaccines, meals, and different issues can have an effect on how the treatment works. These results are known as interactions.
Orilissa can work together with a number of different medicines, in addition to some dietary supplements and probably sure meals.
Before taking Orilissa, discuss together with your physician and pharmacist. Tell them about all prescription, over-the-counter, and different medicine you’re taking. Also inform them about any nutritional vitamins, herbs, and dietary supplements you employ. Sharing this info might help you keep away from potential interactions.
Drug interactions
Below is a listing of medicines that may work together with Orilissa. This checklist doesn’t include all medicine which will work together with Orilissa. If you will have questions on drug interactions which will have an effect on you, ask your physician or pharmacist.
Drug group or drug titleDrug examples
sure contraception capsules that include estrogen• ethinyl estradiol/drospirenone (Gianvi, Loryna, Nikki, Yasmin, Yaz)
• ethinyl estradiol/norethindrone (Leena, Nortrel, Ortho-Novum, Ovcon)
• ethinyl estradiol/levonorgestrel (Altavera, Amethia, Daysee, Lessina, Seasonique)
contraception capsules that include progestin• norethindrone (Nor-QD, Jolivette)
• ethinyl estradiol/drospirenone (Gianvi, Loryna, Nikki, Yasmin, Yaz)
the contraception vaginal ring, ethinyl estradiol/etonogestrel (NuvaRing)—
clarithromycin—
sure antifungals• itraconazole (Sporanox)
• ketoconazole
cyclosporine(Gengraf, Neoral, Sandimmune)—
gemfibrozil (Lopid)—
carbamazepine (Tegretol)—
sure coronary heart medicines• digoxin (Lanoxin)
• rivaroxaban
amlodipine (Norvasc)—
rosuvastatin (Crestor)—
zolpidem (Ambien)—
Other interactions
Orilissa may work together with different substances, corresponding to:
Vitamins or dietary supplements: Orilissa can work together with the natural complement St. John’s wort. Taking them collectively can lower Orilissa ranges in your physique, inflicting it to not work as nicely.
Foods: Eating grapefruit or consuming grapefruit juice whereas taking Orilissa may result in elevated ranges of the drug in your physique. Talk together with your physician or pharmacist about how a lot, if any, grapefruit is protected to devour when you’re taking Orilissa.
Alcohol: Alcohol isn’t identified to work together with Orilissa. But it’s doable that consuming alcohol could make sure negative effects of Orilissa worse. These embody sizzling flashes, headache, nausea, and temper adjustments. Also, alcohol can generally worsen signs of endometriosis, which Orilissa is used to deal with. If you drink alcohol, ask your physician how a lot is protected so that you can devour whereas taking Orilissa.
Pregnancy and breastfeeding
It’s not protected to take Orilissa whereas pregnant. Doing so can result in being pregnant loss.
Taking Orilissa may cause adjustments to your menstrual cycle, which may make it more durable to know if you happen to’re pregnant or not. If you assume you might be pregnant, contact your physician immediately. If you’re pregnant, you’ll have to cease taking Orilissa immediately.
If you’re taking Orilissa throughout being pregnant, you possibly can join the drug’s being pregnant registry by calling 833-782-7241. You may go to the registry web site for particulars and methods to enroll. Your physician may give you extra details about this registry.
It’s not identified whether or not Orilissa is protected to take whereas breastfeeding, or whether or not the drug passes into breast milk. Talk together with your physician about the easiest way to feed your little one whereas taking Orilissa.
Birth management
It’s really helpful that you just use nonhormonal contraception to assist forestall being pregnant when you’re taking Orilissa. And it is best to hold utilizing contraception for not less than 28 days after stopping Orilissa therapy. Condoms and diaphragms are two sorts of nonhormonal contraception strategies.
It’s not really helpful to make use of contraception that comprises estrogen or oral contraception that comprises progestin whereas taking Orilissa. These strategies could make Orilissa much less efficient and will improve the danger of significant issues associated to estrogen, corresponding to blood clots or a stroke. See the “Drug interactions” part above for examples of contraception strategies that may work together with Orilissa.
You can see this text to find out about contraception choices that don’t include estrogen. And your physician might help you select the contraception technique that’s greatest for you.
Other warnings
Orilissa can generally trigger dangerous results in individuals who have sure circumstances. This is called a drug-condition interplay. Other elements can also have an effect on whether or not Orilissa is an efficient therapy choice for you.
Talk together with your physician about your well being historical past earlier than you’re taking Orilissa. Be positive to inform them if any of the next elements apply to you:
osteoporosis
despair
extreme liver issues
earlier allergic response to Orilissa
being pregnant
breastfeeding
Similar medicine
Similar medicine
Other medicine can be found that may deal with your situation. If you’d wish to discover an alternative choice to Orilissa, discuss together with your physician. They can inform you about different medicines that may work nicely for you.
The following medicine are much like Orilissa:
aromatase inhibitors, corresponding to:
letrozole (Femara)
anastrozole (Arimidex)
gonadotropic-releasing hormone (GnRH) agonists, corresponding to:
leuprolide (Lupron Depot)
progestins, corresponding to:
dienogest (Visanne)
norethindrone
Note: Some of those medicines could also be prescribed off-label for endometriosis. Off-label use is when a drug is used to deal with a situation aside from what it’s accepted for.
