Aubagio Interactions: Alcohol, Medications, and Others
Aubagio (generic) is a prescription drug that’s used to cope with quite a few sclerosis (MS). This drug can work along with completely different medication. For occasion, Aubagio can work along with statins, akin to atorvastatin, and positive vaccines.
Aubagio treats clinically isolated syndrome and positive types of quite a few sclerosis (MS) in adults, along with:
relapsing-remitting MS
secondary progressive MS
Aubagio comes as a tablet that you just swallow. It incorporates the energetic ingredient teriflunomide. (An energetic ingredient is what makes a drug work.)
An interaction can occur on account of one substance causes one different substance to have a particular impression than anticipated. Interactions may even occur while you’ve obtained positive properly being circumstances.
Keep finding out to seek out out about Aubagio’s doable interactions. And for further particulars about Aubagio, along with particulars about its makes use of, see this textual content.
When must I avoid Aubagio?
When must I avoid Aubagio?
Certain properly being circumstances or completely different elements may enhance your hazard of damage must you take Aubagio. In such cases, your doctor won’t prescribe Aubagio for you. These are known as contraindications. The itemizing beneath comprises contraindications for Aubagio.
If you’re pregnant. Aubagio has a boxed warning regarding the hazard of points with fetal enchancment (usually known as starting defects). It’s not safe to take Aubagio must you’re pregnant. To research further, see the “Boxed warnings” half merely above or focus on alongside along with your doctor.
If you can have excessive liver points. Aubagio has a boxed warning regarding the hazard of nice liver damage. Due to this hazard, the drug is not prescribed to people who’ve a excessive liver draw back, akin to liver cirrhosis. To research further, see the “Boxed warnings” half merely above or focus on alongside along with your doctor.
If you are taking the drug leflunomide (Arava). Your physique breaks down leflunomide into an lively ingredient* known as teriflunomide. Aubagio’s energetic ingredient may be teriflunomide. If you are taking every medicine, the extent of teriflunomide in your physique can get too extreme. This will enhance your hazard of unfavourable results, along with liver damage. Because of this, your doctor gained’t prescribe every medicine to you directly.
If you’ve had an allergic response. If you’ve had an allergic response to Aubagio, leflunomide (Arava), or any of their elements, your doctor attainable gained’t prescribe Aubagio. This is on account of taking the drug may set off one different allergic response. You can ask your doctor about completely different therapies which can be larger decisions for you.
Before you start taking Aubagio, focus on alongside along with your doctor if any of the elements above apply to you. Your doctor can determine whether or not or not Aubagio is safe so to take.
* An energetic ingredient is what makes a drug work.
* Are you looking out for Info & Tips? You can uncover it beneath *
Does Aubagio work along with alcohol?
Does Aubagio work along with alcohol?
Aubagio isn’t acknowledged to work along with alcohol.
However, excessive alcohol consumption may trigger liver damage. And on account of a unusual nonetheless extreme side impression of Aubagio is liver damage, it may be most safe to limit alcohol consumption whereas taking Aubagio.
If you’d want to research further about alcohol and Aubagio, focus on alongside along with your doctor.
Does Aubagio work along with completely different medicine?
Does Aubagio work along with completely different medicine?
Before you start taking Aubagio, inform your doctor and pharmacist about any prescription or over-the-counter medicine you are taking. Sharing this information with them may help cease doable interactions. (To research whether or not or not Aubagio interacts with dietary dietary supplements, herbs, and dietary nutritional vitamins, see the “Are there other interactions with Aubagio?” half beneath.)
If you can have questions on drug interactions which is able to affect you, focus on alongside along with your doctor or pharmacist.
The desk beneath lists medicine which is able to work along with Aubagio. Keep in ideas that this desk doesn’t embody all medicine which is able to work along with Aubagio. For further particulars about a couple of of those interactions, see the “Drug interactions explained” half beneath.
Drug group or drug titleDrug examplesWhat can happen
warfarin—warfarin is also a lot much less environment friendly
contraception capsules• ethinyl estradiol/ levonorgestrel (Altavera, others)
• ethinyl estradiol/ drospirenone/levomefolate (Beyaz, others)elevated hazard of unfavourable results from contraception capsules
medicine broken down by CYP2C8*• pioglitazone (Actos)
• repaglinide
• paclitaxel (Abraxane)elevated outcomes and hazard of unfavourable results from medicine on this group
medicine broken down by CYP1A2*• duloxetine (Cymbalta)
• theophylline (Theo-24)
• tizanidine (Zanaflex)medicine on this group is also a lot much less environment friendly
medicine that rely on positive transport proteins† in your physique• statins, along with atorvastatin (Lipitor)
• methotrexate (Otrexup, others)
• furosemide (Lasix)
• ciprofloxacin (Cipro)elevated outcomes and hazard of unfavourable results from medicine on this group
cholestyramine (Prevalite)—Aubagio is also a lot much less environment friendly or not environment friendly
* CYP2C8 and CYP1A2 are enzymes (proteins) that help break down positive medicine in your physique.
† Transport proteins switch medicine in your physique. For occasion, they may switch the drug out of your blood and into an organ the place the drug works.
Drug interactions outlined
Drug interactions outlined
Learn further about positive drug interactions which will occur with Aubagio.
Drugs that rely on positive transport proteins in your physique
Aubagio interacts with medicine that use positive transport proteins in your physique.
Transport proteins help switch medicine spherical inside your physique. For occasion, a transport protein may help a drug get to the kidneys, the place it will be broken down and eradicated out of your physique.
Examples of medicines that rely on transport proteins embody:
statins, akin to atorvastatin (Lipitor) and rosuvastatin (Crestor)
methotrexate (Otrexup, others)
rifampin (Rimactane)
What may happen
Aubagio blocks the train of positive transport proteins. This may trigger medicine that rely on these transport proteins to assemble up in your physique.
A greater drug diploma will enhance the outcomes of a drug. It may even enhance the possibility of unfavourable results. And must you already experience unfavourable results, it may truly make them worse.
What you’ll be able to do
If you are taking Aubagio with a drug affected by this interaction, your doctor may lower your dosage of that drug. They’ll moreover monitor you intently for unfavourable results from that drug.
Drugs broken down by the enzyme CYP1A2
Aubagio interacts with medication that are broken down by the enzyme CYP1A2. (An enzyme is a form of protein.)
Examples of medicines broken down by this enzyme embody:
duloxetine (Cymbalta)
theophylline (Theo-24)
tizanidine (Zanaflex)
What may happen
Aubagio quickens the train of CYP1A2. This can decrease the extent of the alternative drug in your physique. This can lower the impression of that drug so that it won’t work as properly to cope with your state of affairs.
What you’ll be able to do
If you are taking Aubagio with a drug affected by this interaction, your doctor may monitor you intently to make sure that the alternative drug stays to be working to cope with your state of affairs. If it isn’t, they might enhance your dosage of that drug.
Drugs broken down by the enzyme CYP2C8
Aubagio interacts with medicine that are broken down by the enzyme CYP2C8. Examples of these medicine embody:
pioglitazone (Actos)
repaglinide
paclitaxel (Abraxane)
What may happen
By blocking the CYP2C8 enzyme, Aubagio will enhance the extent of the alternative drug in your physique. This can enhance the impression of that drug. It may even enhance the possibility of unfavourable results from that drug. And must you already experience unfavourable results from that drug, it may truly make them worse.
What you’ll be able to do
If you are taking Aubagio with a drug affected by this interaction, your doctor may lower your dosage of the alternative drug. They’ll moreover monitor you intently for unfavourable results from that drug.
Are there completely different interactions with Aubagio?
Are there completely different interactions with Aubagio?
Aubagio may produce different interactions. They may occur with dietary dietary supplements, meals, vaccines, and even lab exams. See beneath for particulars. Note that the information beneath would not embody all completely different doable interactions with Aubagio.
Does Aubagio work along with dietary dietary supplements?
Before you start taking Aubagio, focus on alongside along with your doctor and pharmacist about any dietary dietary supplements, herbs, and dietary nutritional vitamins you are taking. Sharing this information with them may help you to avoid doable interactions.
If you can have questions on interactions which is able to affect you, focus on alongside along with your doctor or pharmacist.
Aubagio and herbs
There are presently no research of Aubagio interacting with herbs. But this doesn’t indicate that interactions with herbs gained’t be acknowledged ultimately.
For this goal, it’s nonetheless important to confirm alongside along with your doctor or pharmacist sooner than taking any of these merchandise whereas taking Aubagio.
Aubagio and dietary nutritional vitamins
There are presently no research of Aubagio interacting with dietary nutritional vitamins. But this doesn’t indicate that vitamin interactions gained’t be acknowledged ultimately.
Always confirm alongside along with your doctor or pharmacist sooner than taking any dietary nutritional vitamins whereas taking Aubagio.
Aubagio interactions with dietary dietary dietary supplements
Aubagio interacts with dietary dietary dietary supplements that comprise activated charcoal, akin to Charco-Caps. Activated charcoal causes Aubagio to be cleared out of your physique further quickly than conventional. This makes Aubagio a lot much less environment friendly or not environment friendly.
In actuality, your doctor might need you ever take activated charcoal to help clear Aubagio out of your physique after you stop taking Aubagio. You mustn’t take activated charcoal merchandise all through Aubagio treatment besides your doctor recommends it.
Always confirm alongside along with your doctor or pharmacist sooner than taking any dietary dietary dietary supplements whereas taking Aubagio.
Does Aubagio work along with meals?
There are presently no research of Aubagio interacting with meals. If you can have questions on consuming positive meals all through your treatment with Aubagio, focus on alongside along with your doctor.
Does Aubagio work along with vaccines?
It’s helpful that you just avoid receiving dwell vaccines whereas taking Aubagio. Live vaccines comprise a weakened nonetheless dwell mannequin of the germ they defend in direction of.
You cannot get sick from most vaccines. But taking Aubagio weakens your immune system. And while you’ve obtained a weak immune system, it’s doable to get sick from a dwell vaccine.
Examples of dwell vaccines embody:
measles, mumps, and rubella (MMR) vaccine
nasal spray flu vaccine (LAIV or FluMist)
yellow fever vaccine
Before you begin taking Aubagio, focus on alongside along with your doctor about any vaccines you may want. If they advocate one in every of many dwell vaccines, they might present the vaccine sooner than you start treatment.
Does Aubagio work along with lab exams?
Aubagio isn’t acknowledged to work along with lab exams.
Does Aubagio work along with cannabis or CBD?
There are presently no research of Aubagio interacting with cannabis (usually known as marijuana) or cannabis merchandise akin to cannabidiol (CBD). But as with each drug or complement, focus on alongside along with your doctor sooner than using cannabis with Aubagio.
Note: Cannabis is towards the legislation at a federal diploma nonetheless is permitted in plenty of states to varied ranges.
Does my properly being historic previous affect whether or not or not I must take Aubagio?
Does my properly being historic previous affect whether or not or not I must take Aubagio?
Certain medical circumstances or completely different properly being elements may enhance the possibility of interactions with Aubagio. Before taking Aubagio, focus on alongside along with your doctor about your properly being historic previous. They’ll determine whether or not or not Aubagio is finest for you.
Health circumstances or completely different elements which can work along with Aubagio embody:
Diabetes. Adults older than age 60 years who’ve diabetes might need the following hazard of nerve damage from Aubagio. This unusual nonetheless extreme side impression may affect adults on this age group with diabetes on account of they might already have nerve damage from extreme blood sugar. If you can have diabetes, focus on alongside along with your doctor to review further regarding the hazard of nerve damage from Aubagio and what indicators to look at for.
High blood pressure. Aubagio can enhance your blood pressure. You have the following hazard of this occurring if you already have hypertension. Your doctor might have to control your blood pressure medication while you’re taking Aubagio. Your doctor will monitor your blood pressure all through your treatment.
Liver points, akin to fatty liver sickness. Doctors may avoid prescribing Aubagio counting on the severity of your liver draw back. See the “Boxed Warnings” half above to review further.
Pregnancy. You mustn’t take Aubagio whereas pregnant. See the “Boxed Warnings” half to review further.
Breastfeeding. Breastfeeding whereas taking Aubagio is not helpful. If you’re breastfeeding or planning to take motion, focus on alongside along with your doctor about your decisions.
Allergic response. If you’ve had an allergic response to Aubagio or any of its elements, your doctor will attainable not prescribe Aubagio. This is on account of taking the drug may set off one different allergic response. You can ask your doctor about completely different therapies which can be larger picks for you.
How can I cease interactions?
How can I cease interactions?
Taking positive steps might enable you avoid interactions with Aubagio. Before starting treatment, focus on alongside along with your doctor and pharmacist. Things to debate with them embody:
Whether you drink alcohol or use cannabis.
Other medication you are taking, along with any dietary dietary supplements, herbs, and dietary nutritional vitamins. Your doctor or pharmacist might enable you fill out a drugs itemizing.
What to do must you start taking a model new drug all through your Aubagio treatment.
It’s moreover important to know Aubagio’s label and completely different paperwork which is able to embrace the drug. Colored stickers that describe interactions is also on the label. And the paperwork (usually known as the affected individual package deal deal insert or therapy info) may produce different particulars about interactions. (If you did not get paperwork with Aubagio, ask your pharmacist to print a replica for you.)
If you can have hassle finding out or understanding this information, your doctor or pharmacist might assist.
Taking Aubagio exactly as prescribed may even help cease interactions.
What must I ask my doctor?
What must I ask my doctor?
If you proceed to have questions on Aubagio and its doable interactions, focus on alongside along with your doctor.
Questions you may have to ask your doctor embody:
Can I nonetheless take Aubagio even when it interacts with a drugs I take?
Do any of my properly being circumstances require me to be monitored further intently all through treatment with Aubagio?
What must I do if I’m prescribed a model new therapy that interacts with Aubagio?
Do I have to let if I alter my weight reduction plan whereas taking Aubagio?
To research further about Aubagio, see these articles:
All About Aubagio
Side Effects of Aubagio: What You Need to Know
All About Aubagio’s Dosage
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Disclaimer: skilled has made every effort to make it possible for each information is factually proper, full, and up to date. However, this textual content should not be used as another choice to the information and expertise of a licensed healthcare expert. You must on a regular basis search the recommendation of your doctor or one different healthcare expert sooner than taking any therapy. The drug information contained herein is subject to change and is not speculated to cowl all doable makes use of, directions, precautions, warnings, drug interactions, allergic reactions, or opposed outcomes. The absence of warnings or completely different information for a given drug would not level out that the drug or drug combination is safe, environment friendly, or acceptable for all victims or all explicit makes use of.
